声明:作者并非医学相关专业，内容仅供参考;转载请保留此信息!  作者:MayfieldT 致谢:Jackie

问题:在COVID-19大流行的基础上，如何合理用药应对:1)普通感冒造成的发烧;2)疑似COVID-19造成的发烧

1) 宣称可以使用的药物 a) Tylenol 泰诺 / Paracetamol 扑热息痛 / Acetaminophen 对乙酰氨基酚

备注:泰诺不是NSAID

No, Tylenol (acetaminophen) is not classified as an NSAID (nonsteroidal anti- inflammatory drug). 来自 https://www.drugs.com/medical-answers/tylenol-nsaid-3002124/

2) 宣称不宜使用的药物 a)Ibuprofen / 布洛芬(e.g. Advil)(一般感冒发烧可用)

备注:NSAID 非甾体抗炎药

备注:关于ACE2受体 SARS-CoV-2 uses the SARS-CoV receptor ACE2 for host cell entry来自 https://www.cell.com/cell/fulltext/S0092-8674(20)30229-4

理由:ACE2受体表达

ACE2 can also be increased by thiazolidinediones and ibuprofen. These data suggest that ACE2 expression is increased in diabetes and treatment with ACE inhibitors and ARBs increases ACE2 expression. Consequently, the increased expression of ACE2 would facilitate infection with COVID-19. We therefore hypothesise that diabetes and hypertension treatment with ACE2-stimulating drugs increases the risk of developing severe and fatal COVID-19.

来自

https://www.lefigaro.fr/sciences/coronavirus-alerte-sur-l-ibuprofene-et-autres- anti-inflammatoires-20200314?from=groupmessage&isappinstalled=0

b)NASID / 其他非甾体抗炎药 备注:阿司匹林等

理由:可能存在的ACE2受体表达增加https://lecom.edu/nsaids-and-ace-inhibitors/

b)糖皮质激素(并非常用药物) 备注:可的松等

 理由:长期服用不良反应大